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Lipid Metabolism In the SURPASS and SURMOUNT phase 3 clinical trial programs (Tables 1 and 2), treatment with tirzepatide was related to an improvement in the lipid profile, with major decreases in triglycerides (Table 4) that cannot be fully accounted for by reductions in weight alone [77]

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Relatedly, very few systematic reviews were identified in the scoping review that assessed combination interventions (e.g., two or more interventions, including at least one pharmacological intervention) as the primary objective of the review